A Template-Mediated Click-Click Reaction: PNA-DNA, PNA-PNA (or Peptide) Ligation, and Single Nucleotide Discrimination
نویسندگان
چکیده
منابع مشابه
Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA).
New PNA analogues derived from aminoethylpyrrolidin-5-one backbone show stabilization of aepone-PNA:DNA hybrids and destabilization of the corresponding RNA hybrids compared to unmodified PNA.
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The scope of the Cu(I)-catalyzed [2 + 3] azide/alkyne cycloaddition (CuAAC, click chemistry) as a key reaction for the conjugation of ferrocene derivatives to N-terminal functionalized PNA oligomers is explored herein (PNA: peptide nucleic acid). The facile solid-phase synthesis of N-terminal azide or alkyne-functionalized PNA oligomer precursors and their cycloaddition with azidoferrocene, eth...
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The facile side-specific insertion, on the solid phase, of one or two ferrocene moieties into peptide nucleic acid (PNA) oligomers by click chemistry is presented.
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In Whiplash PCR WPCR autonomous molecular compu tation is achieved by the recursive self directed polymerase extension of a mixture of DNA hairpins A barrier confronting e cient implementa tion however is a systematic tendency for encoded molecules towards backhybridization a simple form of self inhibition In order to examine this e ect the length distribution of extended strands over the cours...
متن کاملExtension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry
Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity, nucleic acids (DNA/RNA) increasingly are in the focus of the scientific interest. While nucleic acids were a target of therapeutic interventions up to now, they could serve as excellent tools in the future, being highly sequence-specific...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2010
ISSN: 1434-193X
DOI: 10.1002/ejoc.201000615